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Another importantvariable to consider is the type of biological assay performed to measure “gain offunction” of p53 in response to treatment with chemo or radiotherapy. The down-ward movement of the muscle enlarges the thoracic cavity area, allowing airto flow into the lungs to equalize pressure

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Classical pathognomonic radiological signs in plain radiographs are thepresence of involucra and/or sequestra, which are, however, only seen in a minority ofpatients. Mention one single investigation which will help in diagnosis or exclude other diagnosis. An enzymeused in the identification and measurement of the activityof enzymes present in liver cells.

Important is an assess-ment according to reasonable degree of skill, knowledge, and reasonable care with com-plementing careful documentation. Although diagnosis based on consensuscriteria (McKhann et al., 1984; American Psychiatric Asso-ciation, 2000) is reasonably accurate by comparison withthe gold standard of pathology at autopsy (Jobst et al.,1998; Knopman et al., 2001), approximately 10% of com-munity-dwelling elderly still have undiagnosed dementia(Solomon et al., 2000; Lopponen et al., 2003)

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